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Similar content being viewed by others The tumour suppressor p53 The p53 gene (generic name used here, also known as TP53 in humans and Trp53 in mouse) encodes the tumour suppressor protein p53 (TP53/TRP53), a transcription factor that can regulate diverse cellular processes, including apoptotic cell death, adaptation of cellular metabolism, cell cycle arrest, cellular senescence and DNA damage repair [1] (Fig