In the respiratory tract, smoking exacerbates inflammation, leading to increased mucus production, impaired ciliary function, and airway remodeling, which worsen the pathophysiology of respiratory diseases [15, 16]

I remember seeing the late, great SNL legend Phil Hartman bring it up on a late night talk show sometime in the late 80s-early 90s, saying there was a videotape of it being passed around through his comedy buddies, but it didnt gain real notoriety until another comedy legend (that thankfully is still with us) Chris Elliot parodied Shatners spoken word spectacle on an episode of Late Night with David Letterman on June 12, 1992: Since then its also been targeted by Beck (from the 1997 video for Where its At): And Family Guy (And the Wiener is... S3E5, broadcast on August 8, 2001: Whats funny about these takes is that none of them really satirizes what Shatner did in his immaculate presentation of the iconic pop classic, they just do what he did as it cant *be* parodied, only imitated
Part of that is due to smoke irritation, but part is due to chronic changes from tissue inflammation increases
A push-button vape pen will activate the battery, heating the e-liquid when you press the button down
F17.210 - Nicotine dependence, cigarettes, uncomplicated: This code is dedicated to patients with current nicotine dependence due to cigarette smoking and hasn't yet developed any associated complications