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381 Furthermore, phosphorylation of h-cGAS by AKT, cyclin-dependent kinase 1 (CDK1), protein kinase, DNA-activated, catalytic subunit (PRKDC, also known as DNAPK), and aurora kinase A (AURKA) has been shown to inhibit its enzymatic activity

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Approach Extended On-cycle 5-6 weeks Off-cycle 6 weeks minimum Best for Used only after prior cycles confirmed glucose tolerance

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