Hormonal and age factors play a role
The global prevalence of diabetes continues to rise, with projections indicating a substantial increase in disease burden over the coming decades ( Patients with T2DM and ESRD represent a particularly high-risk population characterized by advanced metabolic dysfunction, a high burden of cardiovascular disease, and extensive polypharmacy ( Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) improve glycemic control by increasing glucose-dependent insulin secretion, suppressing glucagon release, delaying gastric emptying, and inducing weight loss
N Engl J Med, 375:311-322
As such, the technique is often combined with or centrifugation forgone in favor of, the addition of an IGFBP blocking agent. IGF-2 has proved useful in this regard, being added in excess to samples to reduce interference from residual IGFBPs but methods are not consistent across different IGF-1 assays [112]
Originally for Type 2 diabetes , they are now widely used for weight loss and reducing cardiovascular risks in at-risk patients
