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Notably, the combination was highly active against the OPM-2 xenograft model, which has a translocation t(4;14)

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They still require clinical judgment, nutrition strategy, resistance training, monitoring, and long-term planning

After 29 weeks of diet induction (week-3 relative to start of treatment) a pre-treatment liver biopsy was performed as described in detail previously 44 to select animals for stratification and randomization based on histological assessment