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Kawata, T

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Individuals with T21 are known to exhibit an increased risk of impaired glucose metabolism, insulin resistance, and mitochondrial dysfunction, which collectively contribute to altered energy utilization and elevated cardiometabolic risk 53,54

"Even people that are pretty healthy, boy, they're thinking about [GLP-1s] because my patients are rational and they understand this is evidence-based, and it does seem to have some longevity benefit." He doesn't broadly recommend the entire class of compounds, though

(2011) The efficacy and safety of intramuscular injections of methylcobalamin in patients with chronic nonspecific low back pain: a randomised controlled trial