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Secondary Effects of GLP-1 Agonists: Acute GI Symptoms vs Chronic Gut Microbiome Dysbiosis Some secondary effects of GLP-1 RAs are symptomatic and relatively acute, such as gastrointestinal (GI) changes (constipation, diarrhea, nausea and vomiting), therefore mitigation strategies are well known

However, if the duration of inflammation is prolonged, pathologic (i.e., chronic) inflammation occurs, resulting in adverse effects on brain function due to excessive or sustained release of cytotoxic factors

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The two most common complaints about carnitine supplements are slow onset and caffeine-driven side effects