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This would be problematic in a case where the ACO's financial performance in the BY corresponding to the performance year that was financially reconciled is atypically high because it would upwardly bias the prediction of the ACO's financial performance for a given performance year within the current agreement period

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For all cancer sites, the adjusted hazard ratio was 1.10 (95% CI: 1.081.13) for former smokers, 1.13 (95% CI: 1.111.15) for new current smokers, 1.30 (95% CI: 1.281.33) for the decreasing light smokers, 1.45 (95% CI: 1.431.48) for the steady moderate smokers, and 1.53 (95% CI: 1.491.58) for steady heavy smokers

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It accelerates ovarian aging and lowers egg count