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The defining pathological feature of PD is the selective degeneration of dopaminergic neurons in the substantia nigra pars compacta [4, 186]

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The protein ADAM metallopeptidase with thrombospondin type 1 motif 2, which is specifically associated with the activation of D1-like receptors, may be linked to key biologic mechanisms in schizophrenia and the clinical response to antipsychotics (Ruso-Julve et al., 2019)