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Patients with DMT2 and obesity often have increased levels of DPP-4, increasing the cleavage and deactivation of incretin proteins (ie, GLP-1)

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first-line) versus adjunctive roles in the real-world management of adults with CKD and T2D [13, 14]

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Quantification of the mean [ 18 F]FDG signal in the whole brain also showed significantly reduced glucose uptake in GLP-1R KO mice versus control mice ( p = 0.0314)