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112 Animal studies have shown that suppressing the activity of MG53 and SOCS1 improves insulin sensitivity and protects against metabolic dysfunction

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[4] [5] The standard of care remains disease-modifying antirheumatic drugs (DMARDs), including conventional synthetic DMARDs like methotrexate as first-line therapy, with escalation to biological DMARDs or targeted synthetic DMARDs if disease activity remains inadequately controlled, following a treat-to-target approach

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