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By improving blood supply to damaged tissue, the peptide helps deliver oxygen, nutrients, and healing factors that would otherwise struggle to reach poorly vascularized structures like the plantar fascia

CPP-CAND disrupts FOXO4-p53 foci and induces apoptosis through caspase-dependent pathways FOXO4 is progressively recruited to euchromatin foci following senescence induction and is retained in the nucleus of senescent cells through its interaction with p53, contributing to the maintenance of the senescent state 34

doi: 10.3389/fphys.2023.1281071 Received 21 August 2023 Accepted 16 October 2023 Published 31 October 2023 Volume 14 - 2023 Edited by Maria Cavinato, University of Innsbruck, Austria Reviewed by Eleni Mavrogonatou, National Centre of Scientific Research Demokritos, Greece Raghvendra K

TB4 is currently in clinical trials for the treatment of HIV, AIDS and influenza