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At the stimulation dose that achieved the desired effect in the heart cardioinhibition and modest bradycardia most patients reported undesired effects related to vagal innervation of the larynx, including throat pain, cough, hoarse voice, as well as nausea, and vomiting, which were considered to be significant safety issues (De Ferrari et al

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doi: 10.3390/separations10080449 103 AresAMToribioLGarca-VillalbaRVillalgordoJMAlthobaitiYToms-BarbernFAet al