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Mechanistically, circadian control of CI probably reflects the intersection of substrate routing and time-of-day coordination of CI biogenesis, stability and activity

It is used as part of a medically supervised program and is typically combined with nutrition and lifestyle guidance

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4.4 Interactions between cartilage and synovium 4.4.1 Interplay between cytokines released by chondrocytes and synovial cells When cartilage is damaged, chondrocytes release proteoglycan fragments, type II collagen fragments, and diverse injury-associated factors that synovial cell surface pattern recognition receptors (PRRs) can detect, prompting synovial hyperplasia and proinflammatory cytokine secretion (139)

Purity Specification: 99% purity