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drug interactions [1] Phenobarbital is an inducer of CYP 2B6, 3A4, 2C9, and 2C19, which may lead to inadequate levels of medications metabolized by these pathways

For other cardiovascular outcomesincluding the primary outcome, nonfatal myocardial infarction, HF hospitalization, and revascularizationno serious risks of bias, inconsistency, indirectness, or imprecision were identified, nor was publication bias detected

Patients should seek urgent medical care if these symptoms arise

This process is accompanied by the formation of superoxide radicals and hydrogen peroxide, the latter being formed in higher yields