Notably, GLP-1-expressing NTS neurons project to the PAG [69] where GLP-1Rs are highly expressed [66], although it remains unclear what effects GLP-1R agonists have on energy balance in this brain region
Potential Benefits & Indications Some practitioners use sermorelin to help address growth hormone deficiencies, promote lean body mass, support energy levels, or assist with certain aspects of aging
Coskun T, Sloop KW, Loghin C, Alsina-Fernandez J, Urva S, Bokvist KB, Cui X, Briere DA, Cabrera O, Roell WC, et al
Increase SCFA Production Food-based GLP-1 strategies often begin with increasing SCFA production through microbiome-supportive foods such as: resistant starch legumes oats, barley, whole grains high-fiber vegetables polyphenols such as berries, cocoa, pomegranate prebiotics including inulin and GOS High SCFAs support strong GLP-1 signaling and metabolic flexibility
This combination can lead to superior glycaemic control compared to either medication alone
