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Disruption of any one component (for example, gut dysbiosis or a leaky gut lining) can reverberate throughout this interconnected system

As shown in Figure 13, palmatine was docked into the PAS site of AChE (PDB ID = 4EY7) through hydrogen bonding, van der Waals interaction, PI donor hydrogen bonding, Pi-Pi Stacked, and Pi-Pi T-shaped, based on the molecular docking studies, more rational design and structural modification can be performed on the palmatine in the future research, thus enhancing its anti-AD effect

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Serotonergic modulation in the gut-brain axis Here it gets interesting