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1315 For example, elevated glucose concentrations activate the transcription factor carbohydrate response element-binding protein, which indirectly promotes GLP-1 secretion through regulation of target genes in intestinal L cells

Scott et al., 2002

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It may be a fit for patients who: Have appetite regulation challenges Have signs of insulin resistance Have struggled with repeated weight loss attempts Need stronger metabolic support Have not responded as expected to other approaches Have a medical history that supports tirzepatide use Can tolerate the medication appropriately Tirzepatide may be appealing because of its dual-hormone mechanism, but stronger does not always mean better for every person