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(NOTE: There is an ongoing debate about whether 5-Amino 1MQ should be classified as a small molecule or a peptide, but thats a discussion far beyond the scope of this article) It was discovered in 2017 by researchers at the University of Texas who were attempting to discover small, selective, and membrane-permeable inhibitors of an enzyme called nicotinamide N -methyltransferase (NNMT)

In laboratory and pre-clinical research settings, 5-Amino-1MQ is used as a molecular probe to investigate the consequences of NNMT inhibition across multiple metabolic and cellular systems

In the Reynolds et al

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