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When incubated with brain endothelial cells, cotinine and nicotine decrease ZO-1 expression ( Moreover, the comparative effect of TS and e-cig extract showed that downregulation of ZO-1 protein from e-cig was not dissimilar to that from TS extract treatment (Kaisar et al., 2017)

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Methods and analysis This scoping review protocol guided by the Joanna Briggs Institute Manual for Evidence Synthesis and the PRISMA Extension for Scoping Reviews will investigate what is known about the interactions between smoking and epilepsy

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