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Thats why preserving muscle is so important, especially during weight-loss treatments its not just about staying strong, but about keeping our whole body resilient and healthy. In the commentary, the authors suggest that muscle loss due to weight reduction may also exacerbate conditions like sarcopenic obesity characterized by a combination of high body fat and low skeletal muscle mass which contributes to poorer health outcomes, including cardiovascular disease and higher mortality rates

Serious adverse events were actually less common with oral semaglutide (3.9%) than with placebo (8.8%) in OASIS 4

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10.1038/nature15766 48 FranceschiC.GaragnaniP.PariniP.GiulianiC.SantoroA

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