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At the most fundamental level, any injected compound carries the risks of injection itself: site reactions, subcutaneous infections, abscess formation, and in the context of non-sterile preparation, septicemia

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In addition to the results from SURPASS 4, which was designed to provide preliminary evidence for the cardiovascular safety of tirzepatide, a separate analysis pooling all the clinical trials with tirzepatide was used to generate a pre-specified estimate of cardiovascular events [20] (Table 1)