Combining the previously discussed analyses of GPX3 and MYC with GSVA and GSEA pathway enrichment results, the downregulation of GPX3 can lead to ROS accumulation, inducing lipid peroxidation and subsequently triggering ferroptosis in synovial cells
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Plant polyphenols such as quercetin exhibit strong antioxidative and anti-inflammatory activity by scavenging radicals, chelating metals, and activating the Nrf2ARE pathway, thereby upregulating antioxidant enzymes like SOD, catalase (CAT), and glutathione peroxidase (GPx)
When you swallow a standard glutathione tablet, it must survive the highly acidic environment of the stomach and the enzymatic gauntlet of the digestive tract