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Ordinarily, the body manages this on its own

Nauck MA, Kemmeries G, Holst JJ, Meier JJ

Stability studies indicated ORI@CPD-Lipo stored at 4 C for 21 days exhibited no significant changes in appearance or physicochemical properties, and the solution remained homogeneous and stable

Its usually worst during the first few days after dose increases, particularly within 24 to 48 hours of injection

Eur J Clin Pharmacol 17:267274 Guengerich FP, Turvy CG (1991) Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples