Semaglutide is an injection administered at home once per week
Loraine Baraki the timing hypothesis & the brain 1:16:15 What actually kills postmenopausal women 1:17:31 Fitness: the biggest mortality lever 1:20:21 Strength, power & grip 1:25:15 Clinic: where to start when you're overwhelmed 1:30:41 The detraining problem 1:32:38 Trained vs untrained: what's recoverable 1:34:53 The actual plan 1:39:48 Takeaways Resources: Subscribe to BBM Plus for the full unabridged Direct Line: Barbell Medicine coaching and templates: Signal book pre-order: Body composition & metabolism Greendale et al., SWAN body composition, JCI Insight 2019: Lovejoy et al., visceral fat across the transition, Int J Obes 2008: Pontzer et al., daily energy expenditure across life, Science 2021: Karppinen et al., metabolism in midlife women, Eur J Prev Cardiol 2023: Cardiometabolic Matthews et al., lipid changes & the menopause transition, JACC 2009: Janssen et al., menopause & metabolic syndrome (SWAN), Arch Intern Med 2008: El Khoudary et al., AHA Scientific Statement on midlife women, Circulation 2020: Bone Greendale et al., SWAN bone loss across the FMP, JBMR 2012: Siris et al., undiagnosed low BMD & fractures (NORA), JAMA 2001: Watson et al., LIFTMOR, JBMR 2018: Kemmler et al., EFOPS 16-year, Menopause 2017: Kistler-Fischbacher et al., MEDEX-OP, JBMR 2021: Sherrington et al., exercise for preventing falls, Cochrane 2019: ACSM Position Stand: Osteoporosis and Exercise, Med Sci Sports Exerc 1995;27(4):ivii (no DOI) Cognition & mood Greendale et al., SWAN cognition, Neurology 2009: Kravitz et al., sleep in midlife women, Obstet Gynecol Clin North Am 2018: Cohen et al., Harvard Study of Moods and Cycles, Arch Gen Psychiatry 2006: Bromberger & Kravitz, mood and menopause (SWAN), Obstet Gynecol Clin North Am 2011: Livingston et al., Lancet Commission on dementia 2024: Shumaker et al., WHIMS (estrogen+progestin & dementia), JAMA 2003: Espeland et al., WHIMS (estrogen-alone & cognition), JAMA 2004: Gleason et al., KEEPS-Cog, PLoS Med 2015: Henderson et al., ELITE (timing hypothesis & cognition), Neurology 2016: USPSTF, hormone therapy for primary prevention, JAMA 2022: Fitness & mortality Mandsager et al., cardiorespiratory fitness & mortality, JAMA Netw Open 2018: Kodama et al., fitness & mortality meta-analysis, JAMA 2009: Sui et al., fitness & adiposity in older adults, JAMA 2007: Momma et al., muscle-strengthening activity & mortality, Br J Sports Med 2022: Arajo et al., muscle power vs strength & mortality (CLINIMEX), Mayo Clin Proc 2025: Leong et al., grip strength & mortality (PURE), Lancet 2015: Detraining & trained-vs-untrained Troiano et al., accelerometer-measured activity, Med Sci Sports Exerc 2008: Fleg et al., aerobic-capacity decline (BLSA), Circulation 2005: Ratley et al
In particular, whether pharmacological recovery of GLP-1R metabolic function or functional connectivity also restores the other is an interesting question both for medical imaging biomarkers and the development of such drugs
Generally, you can expect to pay anywhere from $260 to $460 per dose, with higher dosages costing more
In fact, optimal blood flow to the scalp and hair follicles is critical for hair growth that scalp massages have been shown to increase the overall thickness of hair due to improved blood flow to the scalp
