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GLP-1 (glucagonlike peptide1) and GIP (Gastric inhibitory polypeptide) are incretin hormones that play a crucial role in regulating glucose levels and promoting weight loss

doi: 10.1016/j.tips.2013.02.002 102 MaciaLTanJVieiraATLeachKStanleyDLuongSet al

It is a progressive condition eventually leading to kidney failure requiring dialysis or kidney transplantation and is associated with premature death, mostly from heart disease

Please see point 10 above

Vildagliptin preserves the mass and function of pancreatic cells via the developmental regulation and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes