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F12 (10/2009 02/2015)
1 Introduction Infertility is defined as the failure to conceive after 12 months or more of regular, unprotected sexual intercourse ( The tumor suppressor protein p53, encoded by TP53 in human and by Tp53 in mice, is a vital regulator of the cellular stress response and a crucial controller of cell fate ( Multiple studies have shown that p53 is closely related to many developmental disorders or diseases, such as stem cell differentiation, cancer, and cardiovascular and neurodegenerative diseases ( 2 p53 and spermatogenesis Spermatogenesis is a unique and complex cell cycle process that is characterized by fine regulation to ensure high-fidelity transmission of genetic material ( Figure 1 ): spermatogonial stem cells (SSCs) differentiate into spermatocytes via mitotic proliferation, spermatocytes transform into spermatids via meiotic division, and spermatids differentiate into spermatozoa ( Figure 1 )
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Getty Nancy Reagan was one of Ronald's closest advisors, but she relied on an extremely unconventional method for making her decisions
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