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Nine compounds were significantly decreased and 8 compounds were significantly increased in the model group compared to the control group (Figure S3c)

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4.2.4 Immune regulation and microbiome regulation Plant-derived extracellular vesicles (PDEVs) demonstrate significant immunomodulatory potential by regulating macrophage polarization toward the M2 phenotype, modulating T-cell subset proportions, and inducing immune tolerance