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It's unclear if these events were directly related to tirzepatide or rapid weight loss, which is another risk factor for gallbladder disease

Many weight loss clinics expand into hormone therapy or broader wellness

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The consistently higher HbA1C levels in the GLP-1 RAs group throughout the study suggesting the pleiotropic effects of GLP1RAs additional to glucose lowering effect 21

At 60 weeks, weight regain begins to plateau and is projected to taper off at 75% of the original weight loss