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Research has shown that chemotherapy can trigger immune evasion of tumor cells, which is a significant contributing factor to patients vulnerability to relapse and high mortality
Additionally, BBR serves as an FXR and TGR5 agonist, pivotal in modulating the metabolic homeostasis of BAs, thereby intervening in liver cirrhosis by mediating the crosstalk between BAs metabolism and gut microbiota (Liu et al., 2022)
Violation of the integrity of the intestinal barrier and its improper functioning can result in the uncontrolled passage of bacterial components, products of bacterial metabolism, and harmful substances, thus leading to systemic inflammation
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