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select trial semaglutide nejm New in the May 29, 2025, issue of NEJM: Sotatercept in Pulmonary Arterial Hypertension (ZENITH phase 3 trial) https://nej.md/4iYkLbj Oral and Cardiovascular Outcomes (SOUL trial) https://nej.md/4hHII5M Upadacitinib for Giant-Cell Arteritis flow trial semaglutide kidney outcomes

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Description

The major clinical trials measured outcomes at 68-72 weeks

2008 Nov;21(10):1066-75

The most common are gastrointestinal: nausea (experienced by 20-40% of patients, usually diminishing over time), vomiting, diarrhea, constipation, abdominal discomfort, and reduced appetite (which contributes to therapeutic effects but can be excessive for some patients)