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They may seem appealing because of convenience or marketing language, but they lack strong clinical backing
Understanding these fundamental differences in mechanism, evidence base, and regulatory status is essential when considering any combination therapy
Pathophysiology of obesity and its associated diseases
In the UK, GLP-1 receptor agonists for weight management are typically prescribed within specialist weight management services for adults with a BMI of 35 kg/m or above (or 32.5 kg/m for people from South Asian, Chinese, other Asian, Middle Eastern, Black African, or African-Caribbean backgrounds) who also have at least one weight-related comorbidity
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