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The figure is conceptual in nature and was developed by the authors based on previously published literature on circadian aging

Clinical evidence indicates that patients with gout commonly display hypercoagulable features, including platelet activation, elevated coagulation factors, increased fibrinogen, and higher D-dimer levels

This is especially relevant for translating lab-scale formulations into clinical-grade materials, where quality control and scalability are often major bottlenecks

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And I will just say one additional thing about this: if you wake up in the morning, you know, and you didn't get enough sleep