the final immunoreactive score for each tumor specimen was calculated by multiplying the staining intensity score by the positive cell percentage score
[DOI] [PubMed] [Google Scholar] 66.Hansen J.G., Tang W., Hootman K.C., Brannon P.M., Houston D.K., Kritchevsky S.B., Harris T.B., Garcia M., Lohman K., Liu Y., et al
Gene therapy using CRISPR-Cas9 and AAV-mediated wild-type OPA1 expression is in preclinical development [178], with CRISPR-based gene editing proven successful in vitro for the OPA1 missense mutation [179]
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