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GHRP-6 produces potent GH release but also significantly stimulates hunger through ghrelin pathway activation

Its minimal tetrapeptide structure and regulatory classification make it particularly valuable for mechanistic investigations involving genomic and epigenetic signaling networks

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Within the hypothalamus, Gipr- expressing cells are localized in the paraventricular, dorsomedial and arcuate nuclei and colocalize with markers for neurons, glia and vascular cells