soul trial oral semaglutide cardiovascular outcomes results 2024 2025 nejm Canadian Perspectives Whiteboard on the soul trial oral semaglutide cardiovascular

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Each complaint alleges GLP-1 manufacturers failed to provide adequate warning that the diabetes and weight loss drugs could cause severe gastrointestinal problems

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Quick Answer: Good candidates for semaglutide include adults with type 2 diabetes requiring improved glycemic control, adults with obesity (BMI 30) or overweight (BMI 27) with weight-related comorbidities, and patients committed to long-term lifestyle modifications alongside medication therapy

However, for those requiring a more aggressive reduction in HbA1c levels, Tirzepatide may offer a more effective solution due to its dual-action mechanism targeting both GLP-1 and GIP receptors