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This is supported by the observation that basal acidification and glycolytic reserve were at basal levels at 24 h, but the compensatory glycolysis was increased at this time point

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Based on experience with similar incretin-based therapies, diarrhoea following a retatrutide dose increase may begin to settle within one to two weeks as the gut adapts

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Importantly, fasting insulin levels and insulin sensitivity only improved in the very low-calorie diet group and combination group