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7th revision of the declaration of Helsinki: good news for the transparency of clinical trials

ERO1A is a FAD-dependent enzyme catalyzing the oxidative folding (formation of disulfide bonds) of secretary proteins in the ER 42,43

The SURPASS program established efficacy in type 2 diabetes across multiple comparators, including head-to-head superiority versus semaglutide on HbA1c reduction in SURPASS-2 (Fras et al., NEJM, 2021)

No Rebound Hunger or Metabolic Adaptation Appetite suppressants that work through central mechanisms (GLP-1 agonists, sympathomimetics, serotonergic agents) typically create tolerance over time, requiring dose escalation, and often produce rebound hunger when discontinued

Elafibranor and nitazoxanide synergize to reduce fibrosis in a NASH model