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For instance, methotrexate (MTX) inhibits ENPP1 activity, activates the cGAS-STING pathway, and synergistically enhances the efficacy with radiotherapy and PD-1 inhibitors, significantly improving the partial response rate of patients with esophageal squamous cell carcinoma

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However, now there is firm understanding of at least one of the bases for this whole body pain, and that's activation of a particular cell type called glia

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No clinical trial has tested this specific combination, but the theoretical basis for synergy is compelling