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Nascas animal studies suggest that acetyl-L-carnitine, a crucial mediator of fat metabolism and energy production throughout the body, plays a special role in the brain, where it works at least in part by preventing the excessive firing of excitatory nerve cells in brain regions called the hippocampus and frontal cortex

2018 Feb 13;9:35

Past saturation, extra agonist molecules produce diminishing returns while the dose-dependent side effects keep climbing

Tolerance develops

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