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462 Additionally, rosuvastatin, fluvastatin, and pitavastatin inhibit the enrichment of CD4 + T cells and endothelial cell apoptosis by decreasing CD69 and TNF-related apoptosis-inducing ligand expression on T cells, leading to improved plaque stability and the alleviation of acute coronary syndrome

doi: 10.1099/mic.0.27017-0 35 KidaY.ShimizuT.KuwanoK

However, long-term risks such as rare adverse effects, metabolic effects over years, effects on bone, gallbladder, and pancreas need phase-3 trials and post-marketing surveillance to ensure the medication is safe for long-term use

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J Neurosci Res 79:700706 Joshi G, Hardas S, Sultana R, St Clair DK, Vore M, Butterfield DA (2007) Glutathione elevation by gamma-glutamyl cysteine ethyl ester as a potential therapeutic strategy for preventing oxidative stress in brain mediated by in vivo administration of adriamycin: implication for chemobrain