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I have had success reducing dosage or frequency, but those individuals are typically on an oral agent as well, such as phentermine, so they have a bridge in the gap left by the GLP-1 reduction." Endocrinology/Diabetes "1

Biochem, 1991;198(1): 52-59

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Considering the widespread expression of GLP-1 receptors in the brain, the authors recommend that future studies should focus on identifying the key neurocircuits involved in mediating the effects of GLP-1 receptor agonists on substance use disorder, as well as determine the specific patient subtypes who are most likely to benefit from these treatments