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[Ref] Cardiovascular Very common (10% or more): Increased heart rate Common (1% to 10%): Hypotension Uncommon (0.1% to 1%): Orthostatic hypotension Increased heart rate was reported with a mean increase of 1 to 4 beats per minute (bpm) across trials, with maximum changes of 10 to 19 bpm in up to 41% of treated adult patients vs 34% placebo, and 20 bpm or more in up to 26% vs 16% placebo

Uric Acid Induces a Proatherothrombotic Phenotype in Human Endothelial Cells by Imbalancing the Tissue Factor/Tissue Factor Pathway Inhibitor Pathway

The studies were conducted using various mouse models to elucidate the role of RAMP1 and RAMP3 in mediating cagrilintides central and metabolic actions [2]

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