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In another study of 178 patients from the SUSTAIN 8 trial on semaglutide, the average proportion of lean mass loss was nearly identical at 40% (1)

These include: Nausea (reported in a significant proportion of participants, particularly during dose escalation) Vomiting and diarrhoea Constipation and abdominal discomfort Decreased appetite , which, whilst contributing to weight loss, can occasionally lead to inadequate nutritional intake Most gastrointestinal effects were described as mild to moderate in severity and tended to diminish over time

(2023, August 21)

These side effects may include nausea, vomiting, diarrhea, constipation, or abdominal pain