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Notably, the dysregulation of ion channel homeostasis in neuronal cells may serve as a critical molecular hub underlying aberrant nociceptive signal transmission

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References [1] Saravanan P, Siddique H, Simmons D, Greenwood R, Dayan C

The promising effects observed in vitro often require sophisticated formulations (e.g., with piperine, nanoparticles) to be partially translated in humans, raising questions about the efficacy of simple dietary intake or standard extracts (50)