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Cytokines, notably interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-), are potent regulators of ECM turnover and can either support or undermine the repair process depending on their concentration and timing

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7 In concert with the ventromedial prefrontal cortex, the hippocampus also integrates emotional and rewardrelated information into experiences, thereby supporting the transformation of episodic memories into semantic and autobiographical forms

The same neurological circuits involved in food cravings are also implicated in addictive behaviours, including alcohol use

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