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Figure 2 3.1 Activation of inflammatory signaling pathways Research indicates that increased intestinal permeability allows endotoxins such as LPS to enter the systemic circulation, where they trigger systemic inflammatory responses by activating the Toll-like receptor 4/nuclear factor kappa-light-chain-enhancer of activated B cells (TLR4/NF-B) inflammatory pathway

Let us take a look at five therapies climbing up the clinical ladder and poised for approval in the coming years

Lactoferrin (Lf) is another highly promising ligand for BBB targeting

Unseld, A

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