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If you take doses too close together, the concentration of the medication in your blood could spike higher than your body is used to

doi:10.1016/J.BBI.2011.05.015 16

And I think the big question is to determine whether improvements in disease activity that we might see, whether they're entirely due to weight loss, or are there actually direct anti-inflammatory effects of these medications, which could be really interesting

The ELEMENT 2 trial showed comparable A1C reductions , with no significant differences in daily insulin requirements between the two medications

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