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In summary, de novo synthesis and regeneration of ASC are both critical for plants to decrease ROS accumulation, eliminate oxidative damage, and enhance stress tolerance

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In addition to iron-catalyzed free radical chain reactions, lipoxygenase (LOXs) can directly oxidize PUFAs and lipid-containing PUFAs in cell membranes, which are considered to have an essential role in ferroptosis [75, 80]