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The volumetric flow rate q , is related to the flow rate per unit area, v , according to Substituting the equation (2) into the equation (1) gives By integrating equation (3) with respect to r , the pressure p t with respect to the injected bolus radius r t at time t is The pressure acting on a unit surface area of the tissue p , is estimated as 27 Then, the permeability k can be expressed as follows